SpeC™ Disk Spe
SPEC: Innovative Monolithic Disk Technology
• No loose sorbent means no channelling of sample • Uniform flow and extraction properties offers robust performance • Low elution volume affords excellent concentration of analyte, improving sensitivity Using an advanced disk design, SPEC delivers superior flow characteristics and trouble free automation. Due to the low volume of the extraction bed, very low elution volumes can be used. This means that in some applications, evaporation and reconstitution steps can be eliminated, resulting in accelerated sample processing times. The combination of low bed masses, ultra-clean base materials and a broad toolbox of selectivities, delivers higher recoveries free of the matrix interferences that can cause ion suppression. SPEC delivers high recoveries at low elution volumes - as low as 100 µL. This is due to the very high surface area yet small physical volume of the monolithic disk. Overall, extraction efficiency is very high for this format of sample preparation product, and the range of functionalities allows fast method development. Unique phases available in SPEC 96-well and SPE Tube formats DAU: This functionalized SPEC disk is specifically designed for the analysis of drugs of abuse in urine. Its unique sorbent chemistry results in excellent sample clean-up and concentration of samples prior to GC/MS and LC/MS. MP1: SPEC MP1 is a mixed-mode, non-polar/SCX monolithic disk ideal for analytes with polar functional groups in plasma. The dual retention mechanism results in cleaner extracts. The SCX functionality strongly binds polar basic analytes allowing rigorous washing steps to be employed. Bond Elut™ Certify™ offers similar selectivity to SPEC MP1. MP3: SPEC MP3 is slightly more polar than MP1, making it ideal for hydrophobic analytes that would bind too strongly to MP1. MP3 chemistry is particularly suited to the extraction of opiate alkaloids from biological fluids.
Note the high recovery (Y Axis) with an average deviation across the 96 wells of just 3.2% (well positions are shown on the X and Z axes). SPEC provides the predictable flow characteristics analysts require for true walk-away automated processing. With SPEC you need not worry about clogging, and as an added benefit, the typically low vacuum pressure requirement prevents cross-talk (e.g. spraying of fast running eluates between wells in the collection plate).
Typical Applications Drugs of abuse, pharmaceutical small molecules
The uniform recovery and reproducibility between wells from the same well plate
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